In a statement to the Associated Press, the couple said they are "two best friends who have decided to part ways as a couple, but look forward to continuing our cherished friendship." This explanation just isn't enough for people who thought Aniston had finally found her perfect match.
What happened? Just last week the Aniston-Theroux home was featured in Architectural Digest and the actress stated, "I look around at my husband and my dogs and our home, and there's nowhere else I want to be." So what went wrong? And why do we care so much?
Dr. Gail Saltz, a psychiatrist with New York Presbyterian Hospital, said it's not unusual for celebrity breakups to have a big impact on the rest of us, especially when it's a seemingly happy couple like this one.
But it's not just about them: Breakup bombshells like this can make us worry about the state of marriage itself, and the ability of anyone to stay together.
"We spend a lot of time hyping celebrity marriages and then hyping celebrity divorces and it gives one the illusion that nobody can stay together," she said. "But that's such an unfair skew... It doesn't have meaning for you or your neighbor, really. Especially since you have no idea what went on inside, no idea as to why they're splitting up."
To be fair, not everyone is bummed out about Aniston and Theroux's breakup. Fans were quick to point out that Aniston's ex-husband Brad Pitt is single now, too.
While an Aniston-Pitt reunion seems unlikely, fans will keep wishing for Aniston's happiness, after all, she's always been there for us. (Cue the "Friends" theme song.)
Lifestyle writer Diane Mapes contributed to this report.