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Drew Barrymore, Toni Collette tear up talking 'Miss You Already'

Go ahead and grab a hanky now — and hang onto it!

If 1988's "Beaches" brought a tear to your eye, get ready for a new female friendship flick that's sure to get the waterworks going again.

Drew Barrymore and Toni Collette stopped by TODAY Wednesday to talk about their film "Miss You Already," which focuses on their on-screen BFF bond and how a serious illness for one impacts them both.

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Toni Collette, Drew Barrymore: Bring tissues to ‘Miss You Already’

Play Video - 3:44

Toni Collette, Drew Barrymore: Bring tissues to ‘Miss You Already’

Play Video - 3:44

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After watching their emotional reactions to making the moving movie, we can't wait to see it for ourselves!

"Miss You Already" opens in theaters nationwide Nov. 6.

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