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updated 6/9/2011 4:30:10 PM ET 2011-06-09T20:30:10

Step 1: See your doc if …

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Biopsy: If a growth is even slightly questionable, your doctor will examine it under a microscope, says Vernon K. Sondak, M.D., a surgical oncologist at the Moffitt Cancer Center. Depending on the growth's size, shape and location, and your preference, your doctor may shave it off with a razorlike instrument, cut it out with a scalpel or punch it out with a device akin to a cookie cutter. You may need a few stitches or surgical tape, and there's a good chance you'll have a tiny scar. That little bit of removed skin goes to a lab, where a pathologist looks for signs of cancerous cells.

Step 2: Get your diagnosis

Negative: If there is no trace of cancer in the tissue sample, you're home free.

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"But if the mole grows back or the area doesn't heal properly, you should go back to your doctor," Dr. Sondak says. And of course, continue to layer on a broad-spectrum sunscreenwith a minimum of SPF 30. Every. Single. Day.

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Precancer: If left untreated, these abnormal cells (possibly from too much sun exposure) can become cancerous over time. The most common form is actinic keratosis, which can look like scaly, red or flesh-colored patches, says Robin Friedman-Musicante, M.D., spokeswoman for the Skin Cancer Foundation.

Possible treatments include chemo in a creamand lasers, radiation or cryosurgery.

Basal Cell Carcinoma: This is the most common type of skin cancer— 2.8 million cases are diagnosed yearly. It forms on skin's surface and can be a pearly-pink bump or dry, reddish-brown patch. Although rarely fatal, it can damage nearby skin tissue and eventually invade muscles, nerves and bones if untreated.

Possible treaments include chemo in a cream; lasers, radiation or cryosurgery; Mohs surgery; and standard surgery.

Squamous Cell Carcinoma: The second most common skin cancer can be any color and look hard, crusty and wartlike, or rough and scaly with raised edges. It can also develop from a burn, scar or sore when normal healing goes awry. And it's more apt to migrate deep into skin and nearby lymph nodes.

Possible treaments include lasers, radiation or cryosurgery; Mohs surgery; and standard surgery.

Melanoma: Less than 5 percent of skin cancers are melanoma, but they lead to more than 75 percent of all skin cancer deaths. A result of both sun damage and genetics, melanoma can pop up anywhere. Spots often look like a mole gone bad—a flat or raised area that's black, brown or multicolored with a jagged border.

Possible treaments include standard surgery.

Step 3: Go for treatment

Chemo in a Cream: If cancer hasn't penetrated past the very top layer of skin, docs may try a topical form of chemotherapy. Imiquimod can stimulate the immune system to destroy cancerous and precancerous cells; 5-fluorouracil halts the growth of cancer cells as intravenous chemo does.

What it's like: "At first, my skin turned red, then it got crusty and inflamed," says Gwen, 40, of New York, who used imiquimod on a basal cell carcinoma. "I applied it every other day for six weeks, and there was actually a hole in the spot! It was very uncomfortable — itchy and tight, and it burned. But six weeks after I stopped, the area was healed, and there is no scar."

Lasers, Radiation or Cryosurgery: Even a basal or squamous cell cancer that doesn't yet require surgery can be too deep in skin for a cream to reach it. Lasers target and destroy cancerous cells, which then flake off; liquid nitrogen cryotherapy freezes cells (the same way it's used to remove warts); brachytherapy is spot-specific radiation.

What it's like "It feels as if your skin is both freezing and burning at the same time," says Amy, 46, of Avon, Connecticut, who experienced cryotherapy treatments for precancers on her arms, hands and face. "Then a fluid-filled blister forms, which bursts after two days. Only a little bit of redness is left, which fades."

Mohs Surgery: To remove nonmelanoma cancers that have burrowed into skin's dermis or show potential for spreading, surgeons often use this surgery technique. The area is numbed, then thin layers of skin are sliced with a scalpel and checked under a microscope for cancerous cells. Your doc will cut gradually until there's no sign of cancer.

What it's like: "The cancer had spread almost to my eye, and the doctor had to cut a ¾-inch-wide hole. It was too big to stitch up, so she grafted skin from near my left ear," says Maureen, 32, of Washington, D.C., who had a basal cell carcinoma on her nose. "I stayed home for a week so it could heal. A year later, I still had a scar in that spot."

Standard Surgery: Traditional surgery is the primary method of removing melanoma, the deadliest form of skin cancer, as well as basal or squamous cell cancers that aren't in cosmetically sensitive zones (i.e., your face). If you had melanoma, you may need a skin graft or another type of reconstructive surgery and another biopsy to see if the cancer has spread. If so, treatment could include further surgery, immunotherapy, chemotherapy or radiation.

What it's like: "My melanoma just looked like a large freckle, but my doctor still had to cut out a lot of skin," says Emily, 27, of San Francisco. "I have a 4-inch scar on my shoulder blade. It reminds me to keep track of every freckle and mole."

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