Katie Couric, the first woman in the nation to serve as solo network evening news anchor, will end her stint on "CBS Evening News" on Thursday by interviewing another history-making woman, U.S. Secretary of State Hillary Clinton.
Couric, 54, will discuss President Barack Obama's foreign policy speech on developments in the Arab world with Clinton, who sought the presidency in 2008, CBS said.
Clinton became the first former first lady to win elected office when she joined the U.S. Senate in 2001.
Couric's final show, capping a sometimes troubled run that began in September 2006, was slated to look back at her years in the CBS anchor chair.
CBS also posted Couric's final "video notebook" online, in which she ruminated about her struggle when she began as anchor to come up with a good sign-off line.
After thanking her CBS colleagues in the last notebook, Couric said she decided it was best to stick with the line there she originally settled on: "I'm Katie Couric. Thanks for watching. Good night."
"60 Minutes" reporter Scott Pelley will succeed Couric, whose contract is up in June, on June 6.
Couric moved to CBS News after 15 years as co-host of NBC's top-rated morning show, "Today," and at the time spoke of plans to revamp and update the nightly network news format.
She won a number of prestigious awards during her relatively brief tenure and scored some journalistic coups, notably her interview with Republican vice presidential nominee Sarah Palin in 2008, in which Palin seemed ill-prepared.
But she never managed to lift "CBS Evening News" out of third place behind "NBC Nightly News" and "ABC World News."
Couric is reported to be in talks to develop a daytime talk show.