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 / Updated  / Source: TODAY
By Chris Serico

Giuliana Rancic's hopes of becoming a biological parent for a second time may have ended with her surrogate's recent miscarriage.

Celebrity Sightings - February 13, 2015 - Fall 2015 Mercedes-Benz Fashion Week
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Although the TV personality and her husband Bill celebrated the birth of their son Duke via surrogate in August 2012, Giuliana's three remaining embryos were lost in two subsequent miscarriages, the most recent of which the couple learned about Dec. 31.

“It was painful,” Giuliana told People magazine in an exclusive interview posted online Wednesday. “We were so optimistic with this last embryo. We thought, ‘This is definitely going to work. This is our last shot.’”

Earlier in 2014, their surrogate miscarried the other two embryos a few weeks after they were implanted. But Giuliana called the more recent miscarriage the "toughest blow," adding, "It was a really hard time."

The couple is exploring other options, including adoption.

“I think adoption is a beautiful gift you're giving each other," she told People. "And it's funny, I'm even more open to [adoption] than I was before. Because I think to myself, 'I love Duke so much, if I couldn't take care of him, I hope there would be someone else who would love him.'"

A breast cancer survivor whose medication may pose pregnancy risks, the entertainment host has been candid about her infertility struggles in interviews and on the E! reality show, "Giuliana & Bill." When Duke made his TV debut on TODAY in July 2013, Giuliana called the boy a "miracle" at the end of what had been a difficult process.

"We didn't know … if we were even going to put him on the [reality] show," she said at the time. "But we felt like people have been through this major journey with us, through infertility and the breast cancer, and then to say, 'You know what? You can't meet our baby.' … It just felt wrong."

Follow TODAY.com writer Chris Serico on Twitter.