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Designers Domenico Dolce and Stefano Gabbana angered Elton John earlier this week when they voiced their opposition to gay adoptions and their support for "traditional marriage" in an interview with the Italian fashion magazine Panorama.
And now Madonna has weighed in on the Dolce & Gabbana founders' controversial comments.
The 56-year-old star responded on Instagram Wednesday, posting an image from a campaign she shot for the upscale fashion brand four years ago in which she holds a baby.
"All babies contain a soul however they come to this earth and their families," she wrote alongside the photo.
"There is nothing synthetic about a soul!! So how can we dismiss IVF and surrogacy?" she continued. "Every soul comes to us to teach us a lesson. God has his hand in everything even technology! We are arrogant to think Man does anything on his own. As above so below! Think before you speak.,,,,,,,,,,,❤️#livingforlove."
John, who has two children born via a surrogate with his longtime partner David Furnish, also took issue with the designers' remarks that kids not born into traditional families are "children of chemistry."
"How dare you refer to my beautiful children as 'synthetic,'" the British singer-songwriter wrote on his own Instagram account on Sunday.
"And shame on you for wagging your judgmental little fingers at IVF — a miracle that has allowed legions of loving people, both straight and gay, to fulfill their dream of having children."
Also on Sunday, the company issued a statement: "We believe firmly in democracy and we think freedom of expression is essential for that. We talked about our way of looking at the world, but it was not our intention to express a judgement on other people's choices. We believe in freedom and love."