She's been rejected by Brad Pitt, Vince Vaughn, John Mayer and, most recently, "Cougar Town" star Josh Hopkins.
And apparently most men and women don't understand why.
Photos: Jen Aniston and John Mayer, the way they were
The currently unattached actress, 41, was voted the most eligible single woman in the world, according to a "60 Minutes"/Vanity Fair poll released Monday.
Photos: Jen Aniston's bikini body through the years
The star (who nabbed 29 percent of the votes) was followed by Halle Berry (21 percent); Elin Nordegren (15 percent); Betty White (11 percent); Lady Gaga (5 percent) and Associate Justice of the Supreme Court of the United States Elena Kagan (4 percent).
Photos: Jen Aniston's red carpet looks through the years
Despite being so unlucky in love, Aniston has said she doesn't want people to pity her.
"This whole 'Poor lonely Jen' thing, this idea that I'm so unlucky in love?" she once told Vogue. "I actually feel I've been unbelievably lucky in love ... I'm right where I'm supposed to be."