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By Scott Stump

In her first live U.S. interview in advance of her upcoming re-trial, Amanda Knox will appear on TODAY Friday to talk about her six-year saga.

Knox, 26, will face her third trial for the alleged murder of British roommate Meredith Kercher while both were students in Italy in 2007. Knox was convicted in 2009 and spent nearly four years in an Italian prison before she and ex-boyfriend Raffaele Sollecito were acquitted on appeal and released on Oct. 4, 2011. In March, the Italian Supreme Court ordered a new trial for Knox, rejecting the appeals court ruling. 

Knox has said she will not return to Italy for the trial, is set to begin in Florence on Sept. 30. She can be represented by her lawyers. 

Knox, who lives in the Seattle area, penned a book, “Waiting to Be Heard,” in which she maintains her innocence and said she was railroaded by the Italian court system. 

After her live interview, Amanda and her sister Deanna will talk to Carson Daly in TODAY's Orange Room about their life and family now.