What is pancreatic cancer? Symptoms, detection, treatment and more

The overall statistics for surviving pancreatic cancer remain grim.

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/ Source: TODAY
By A. Pawlowski

The death of Rep. John Lewis on Friday came just months after he learned he had stage 4 pancreatic cancer last December.

"Jeopardy!" host Alex Trebek, who is undergoing treatment for the same disease, hoped both could complete the year as pancreatic cancer survivors. Trebek recently gave conflicting updates on his condition, saying he's "doing well" in one announcement this month, but revealing his prognosis has gotten worse and that he sometimes feels like "I want to die" in an interview with The New York Times.

Trebek, who was diagnosed in 2019, has been working with the World Pancreatic Coalition to raise awareness and teach people about the symptoms of the deadly disease.

In a public service announcement released last October, Trebek said he wished he had been aware of the warning signs.

"I wish I had known earlier that the persistent stomach pain I experienced prior to my diagnosis was a symptom of pancreatic cancer," he said in the PSA.

What is the survival rate?

The overall statistics remain grim: More than 90% of patients die within five years of learning they have pancreatic cancer, according to the American Cancer Society.

That number rises to 97% of patients whose pancreatic cancer has spread to distant parts of the body, as in Lewis' and Trebek’s case.

Still some people do beat the odds and go on to live for years. Supreme Court Justice Ruth Bader Ginsburg is a long-term survivor. She's currently being treated for a recurrence of liver cancer.

“Nobody knows why these patients live longer than other people with pancreatic cancer, but something is clearly setting them apart,” said Dr. Vinod Balachandran, a member of Memorial Sloan Kettering’s David M. Rubenstein Center for Pancreatic Cancer Research in New York City, in a statement.

He’s the author of a 2017 study that found that “something” seemed to be the robustness of their own immune systems, with long-term survivors having almost 12 times the number of T cells — a type of immune cell that helps the body fight against invaders — inside their tumors than other patients.

What is pancreatic cancer?

The pancreas is a 6-inch long gland that lies between the stomach and the spine, the National Cancer Institute noted. It helps the body break down food and regulate blood sugar.

About 95% of pancreatic cancers begin in exocrine cells, which produce the digestive “juices.”

Pancreatic cancers that begin in endocrine cells — which make hormones like insulin — are far less common, but also less aggressive.

Trebek hasn’t specified which kind of tumor he has, but it’s likely the first type.

What are the symptoms of pancreatic cancer?

The early stage of the disease often causes no symptoms, which is why the cancer is so deadly: It’s usually caught only when it becomes large and spreads outside of the gland. It’s also hidden behind other organs including the stomach, small intestine, liver, gallbladder, spleen and bile ducts.

Since the pancreas is located so deep inside the abdomen, patients won’t feel a lump like they might with breast cancer or notice any other obvious clues, Dr. Anirban Maitra, scientific director of the Pancreatic Cancer Research Center at the University of Texas MD Anderson Cancer Center in Houston, told NBC News.

Symptoms, when they do occur, can be vague and mimic the warning signs of other illnesses. They include:

  • Jaundice, or yellowing of the skin and whites of the eyes
  • Light-colored stools
  • Dark urine
  • Itchy skin
  • Pain in the upper or middle abdomen and back
  • Unexplained weight loss
  • Loss of appetite
  • Feeling very tired
  • Nausea and vomiting

Fewer than 20% of pancreatic cancers are confined to the pancreas when they are found.

What are the risk factors for pancreatic cancer?

There are some risk factors that a person can’t change, including age — with most patients over 65 — and having a family history of pancreatic cancer. Men and African Americans are slightly more likely to develop pancreatic cancer than women and whites.

The National Cancer Institute and the American Cancer Society also list risk factors that people do have influence over. They include:

  • Smoking
  • Being very overweight
  • Workplace exposure to certain chemicals used in the dry cleaning and metal working industries

How is pancreatic cancer diagnosed?

There are currently no approved early detection methods, but researchers hope tests that can pick up biomarkers for the cancer will become available in the next few years.

When patients complain of symptoms, the cancer can be found with imaging tests such as a CT scan, MRI and ultrasound. Certain blood tests, procedures and a biopsy can also help doctors diagnose the disease.

What is the treatment?

Surgery to remove part or all of the pancreas is an option for the minority of people whose pancreatic cancer was detected in its early stages. Ginsburg underwent surgery for it 11 years ago.

Most people with pancreatic cancer receive chemotherapy, according to the Hirshberg Foundation for Pancreatic Cancer Research.

But chemotherapy and radiation can be hit or miss.

"Something that makes pancreatic cancer difficult is the tumor itself is surrounded by a dense microenvironment, so it makes getting the drug delivery difficult," Julie Fleshman, president and CEO of the patient advocacy organization Pancreatic Cancer Action Network in California, told NBC News.

Researchers are investigating targeted therapies based on the molecular makeup of a patient’s tumor.

Certain types of immunotherapy, which stimulates a person’s own immune system to recognize and destroy cancer cells more effectively, can also be used to treat pancreatic cancer, the American Cancer Society noted.