Why do some dogs live really long lives? New findings might provide clues

The genetic findings might help researchers understand what makes a dog healthy into old age and that impacts their humans, too.
/ Source: TODAY

Losing a dog is a gut-wrenching experience for anyone no matter the pup’s age, and many wish their dogs could live longer lives. A recent paper in Frontiers in Genetics (a scientific publisher and research network) examined the genome of two dogs who lived to extremely old ages, 22 and 27 years old, and provides researchers with more information about what contributes to dogs becoming “centenarians.”

“If we better understand the mechanisms of aging in dogs, we can promote a healthier lifestyle for dogs,” Dávid Jónás, a research fellow at the Department of Ethology at Eötvös Loránd University in Budapest, Hungary, told TODAY via email. “If pet dogs live longer and healthier, it could have a positive impact not only on the dogs themselves, but on the mental health of their owners as well.”

Researchers analyzed the genome of two extremely old dogs, Kedves, a 22-year-old female, and, Buksi, a 27-year-old male. Both dogs have since passed away, but their DNA might provide insight into canine aging. Molnar Gerencser

For this study, the researchers sequenced the DNA of two dogs, Kedves, a 22-year-old female, and, Buksi, a 27-year-old male, what researchers called Methuselah dogs. These canines have a 50% longer lifespan than others (much like a human centenarian). Researchers were looking for genes they share that might explain their extended lifespan.

“This was the first study that investigated the genetic background of aging in dogs using whole-genome sequencing methods. We made the complete DNA information of these dogs publicly available for both scientists and the general public,” Jónás, the author of the paper, said. “We identified genes that are probably linked to extreme longevity in dogs.”

So what exactly did these genes reveal? Well, it's a little complicated.

“When we examined the approximately 20,000 canine genes, we found some so-called start- and stop-codon mutations, which might result in disrupted gene functions. It is worth further examining these genes: first to verify that these mutations are true positives, then to investigate their biological effects as well,” noted Sára Sándor, a geneticist who was involved in the research, in a press release.

Some of the genes that overlapped between their two genomes are related to immunity, inflammation and Alzheimer's in humans.

These findings helped them develop a hypothesis for further research with a larger sample size of elderly dogs: “A crucial genetic requirement of extreme longevity lies within the fine-tuning (i.e. the superior calibration) of gene expression.”

While it is too soon to say what this study means for the average dog owner, having a better understanding of canine aging might change how people might think of breeding dogs, said Carlos Alvarez, who was not involved with the research.

“One of the things that (breeders) would like the most is to create healthy dogs,” said Alvarez, a principal investigator at the Research Institute at Nationwide Children’s Hospital in Columbus, Ohio. “The idea of breeding dogs to be healthy is almost overwhelming to think about. However, if you put the question in terms of life span, the fact that you have genetic variations that can increase or decrease lifespan, that's much easier to think about.”

The dogs in this small study enjoyed lives in the countryside that involved a lot of exercise and contact with humans. Molnar Gerencser

Currently, people breed dogs to attain a certain look — such as big eyes or squishy faces — and those looks often impact a pup’s overall health. But this new understanding about aging might change how people think about dogs, Alvarez said.

“We selected very strongly for appearance traits and by doing that we made dogs more susceptible for diseases,” he said. “By doing genetic studies, we can start to think about what we did and select now for health.”

What’s more, the researchers suspect that if they understand what contributes to healthy aging in dogs, they might gain insight into how people age, too.

“It can also contribute to better understanding of the aging process in humans as well, because dogs share the same environment with their owners, which presumably makes the obtained results more relevant and applicable to human studies,” Jónás said.