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A woman who developed an incredibly rare but potentially deadly cancer linked to certain breast implants is warning other women to stay vigilant about their bodies as the number of cases grows.
Stacey Boone was told she had the flu, endured an egg-size lump on her collarbone and lost more than 40 pounds before she finally received the correct diagnosis: breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a type of non-Hodgkin's lymphoma.
On Wednesday, the U.S. Food and Drug Administration announced it has identified 414 women with the disease, or 55 more since the last public update one year ago. Nine patients have died since the FDA found a possible link in 2011, a number that's unchanged from last year. Most cases involve textured breast implants. The agency is closely tracking the developments and gathering more data "so that patients and providers can have more informed discussions about breast implants," said Dr. Binita Ashar, director of surgical devices in the FDA's Center for Devices and Radiological Health, in a statement.
“It has been the hardest road I’ve ever could imagine,” Boone, 51, who lives in Bradenton, Florida, told TODAY. “I wanted to give up so many times.”
Boone underwent breast augmentation surgery in 1990, a cosmetic change she wanted to do for herself, she said. She now knows she received textured breast implants, though at the time, she wasn’t aware she had any options.
“I had no idea what they were putting in me,” Boone recalled. “I didn’t even know there was a difference.”
Textured implants have a rough, irregular surface that makes them less likely to move around inside the breast and reduces the risk of capsular contracture, a common complication that can leave the breast hard and misshapen. In the U.S., textured breast implants make up about 13 percent of the market.
The risk of developing ALCL of the breast is 67 times higher for a person who receives a textured breast implant compared to the general population, said Dr. Mark Clemens, associate professor of plastic surgery at The University of Texas MD Anderson Cancer Center in Houston, who is investigating the link.
That’s still very rare, with a lifetime risk of 1 in 30,000 for U.S. women with textured breast implants, he noted. The latest FDA statement says the risk ranges from 1 in 3,817 to 1 in 30,000 based on studies reported in medical literature.
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Researchers don’t know the exact reason why textured implants would raise the risk, but there are several theories.
It may be that the texturing creates particles that cause abrasion, leading the body’s immune system to develop the disease after a number of years. Or perhaps some women are genetically susceptible to ALCL. Another theory is that a small amount of bacteria on the surface of the implant causes the body to wall it off, but it remains a constant irritant and given enough time — eight to 10 years — it could develop into a lymphoma.
Boone’s problems began in 2013, when she started feeling like she had the flu. Her left breast grew in size, became hard and felt hot to the touch. She also noticed a large lump in her clavicle area.
She was treated for the flu and took antibiotics for three months. But she kept losing weight, going from 140 pounds to 98.
In January 2015, her sister, who is an ultrasound tech, did a scan and found four lumps under Boone’s arm. Boone was diagnosed with stage 4 cancer the next day. She couldn’t believe her implant may have played a role.
“I was shocked. That was the last thing I thought of,” she said. “Worst case scenario, I thought maybe it was leaking.”
Boone underwent four six-week rounds of chemotherapy, plus a stem cell transplant at Moffitt Cancer Center in Tampa, Florida. Both of her breast implants were removed. She says she came close to dying before things turned around. She’ll be three years in remission in June.
“I feel great today,” Boone said. “I have to build my body strength back up. It took a long time for me just to walk from one room to another, it was exhausting. Now, I’m up to five miles a day.”
If you have breast implants:
• There is no need to change your routine medical care and follow-up, the FDA says.
• “Women should just be aware that this can occur and to watch for symptoms, but have a realistic perspective on the disease: it’s incredibly rare,” Clemens said.
• Go to your doctor if you notice something unusual.
• The majority, or 80 percent, of women with breast implant-associated ALCL will have a “spontaneous fluid collection,” which may show up as a sudden enlargement or swelling of the breast, he noted. About 40 percent will feel a mass or a lump.
• One part of the diagnosis is a screening test called CD30. If you don’t get that test, you can miss the disease, Clemens said.
• The treatment for the vast majority of patients is surgery. If the disease progresses to the lymph nodes, it usually requires chemotherapy.