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IMAGE: Oprah sign
Paul Beaty  /  AP
Kimberly Adams of Chicago stands outside Harpo Studios before the final taping of "The Oprah Winfrey Show" in Chicago on May 24.
updated 5/25/2011 9:02:02 PM ET 2011-05-26T01:02:02

While many reacted to the final episode of "The Oprah Winfrey Show" with tears and emotion, comedians found punch lines.

On "Jimmy Kimmel Live," Kimmel sang goodbye by performing the song "End of the Road" with R&B group Boyz II Men. The tune was renamed "It's So Hard To Say Goodbye (to Oprah Winfrey)."

Kimmel serenades Oprah with Boyz II Men

David Letterman, whose up-and-down relationship with Winfrey has long been chronicled, earlier lamented not being invited to the farewell gala in Chicago.

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"Honest to God," said Letterman, "Every day, I get out of bed and think: 'What can I do to suck up to Oprah?'"

Story: Oprah thanks fans as 25-year run comes to end

Many turned to social media to contemplate a post-Oprah world.

Among the notable comments made on Twitter were these:

— "Apparently Oprah is responsible for life on our planet as we know it." — Kevin Nealon.

— "I miss both Oprah and Osama. Is there a way to pair them up for something?" — Michael Ian Black.

— "Oprah Winfrey is so powerful that she had the Rapture postponed until after her final show airs." — Joan Rivers.

— "It seems so unfair! Without Oprah, how are publishers going to continue their cross-fingers/hope-to-win-the-lottery business plan?" — John Hodgman.

— "Jesus will probably be the surprise guest. She got him started." — Paula Poundstone.

— "What can I say about Oprah that she hasn't already said about herself?" — Justin Stangel, co-executive producer of CBS' "Late Show."

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Video: Oprah signs off

Photos: Oprah's farewell spectacular

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  1. A lovely tribute

    Halle Berry, left, Katie Holmes, center, and Queen Latifah attend Surprise Oprah! A Farewell Spectacular at the United Center in Chicago on Tuesday, May 17. "The Oprah Winfrey Show" is ending its run May 25, after 25 years, and millions of her fans around the globe are waiting to see how she will close out a show that spawned a media empire. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  2. Shine a light

    Fans hold up lights as Rascal Flatts perform during a star-studded double-taping of "Surprise Oprah! A Farewell Spectacular" on Tuesday, May 17 in Chicago. (Charles Rex Arbogast / AP) Back to slideshow navigation
  3. A ha-ha moment

    Oprah Winfrey laughs with poet Maya Angelou during the taping of "Oprah's Surprise Spectacular" in Chicago on Tuesday, May 17. Winfrey kicked off one of her last-ever national talk shows on Tuesday with hugs from Tom Hanks, Tom Cruise and Madonna in a packed United Center. (John Gress / Reuters) Back to slideshow navigation
  4. Amazing Aretha

    Aretha Franklin performs "Amazing Grace" for Oprah Winfrey during the Tuesday, May 17 taping. She was introduced by Winfrey's longtime partner, Stedman Graham. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  5. She likes Mike

    Michael Jordan, who lead the Chicago Bulls to six NBA titles in the 1990s, was also among the stars who feted the talk host. He told Winfrey that she inspires him. (Daniel Boczarski / Getty Images Contributor) Back to slideshow navigation
  6. At her side

    Stedman Graham, Winfrey's longtime partner, told her that he loved her and was proud of her during the taping on Tuesday, May 17. "It really does amaze me that I get to be around a woman who changes people's lives every day and who also takes her own lunch to work," Graham told the crowd at the United Center. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  7. Giving thanks

    About 300 Morehouse College scholarship students walked along the United Center aisles as Kristen Chenoweth sang "For Good" from the musical "Wicked" during the Tuesday, May 17 taping. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  8. Oprah and her friends

    Gayle King, left, and Maria Shriver, right, were at Winfrey's side during the taping of "Surprise Oprah! A Farewell Spectacular." Shriver appeared on the same day it was revealed her husband, Arnold Schwarzenegger, fathered a child with a woman on his household staff more than a decade ago. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  9. Lady Madonna

    Pop superstar Madonna said she is among the millions of people who are inspired by Winfrey. "She fights for things she believes in, even if it makes her unpopular," she said. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  10. Serenading Oprah

    "America's Got Talent" phenom Jackie Evancho, left, Patti LaBelle, center, and Josh Groban perform "Somewhere Over the Rainbow" for Winfrey. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  11. Oprah's babies

    Actress Dakota Fanning, surrounded by children, told Winfrey "we call ourselves Oprah show babies. Your voice has been the soundtrack of our lives." (Daniel Boczarski / Getty Images) Back to slideshow navigation
  12. A song just for Oprah

    Stevie Wonder serenaded Winfrey with an original song, singing to her, "Oprah thank you for using your gifts to uplift so many hearts." He also performed "Isn't She Lovely" with Jamie Foxx. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  13. Power couple

    Jamie Foxx pays tribute to Winfrey during "Surprise Oprah! A Farewell Spectacular" at the United Center in Chicago on Tuesday, May 17. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  14. Playing it straight from the heart

    Comedian Jerry Seinfeld was among the many stars who paid tribute to Winfrey. (Daniel Boczarski / Getty Images) Back to slideshow navigation
  15. A Rosie tribute

    Talk-show host Rosie O'Donnell sings during the taping of "Surprise Oprah!" on Tuesday, May 17. O'Donnell has a new show set to debut on Winfrey's OWN network this fall. (John Gress / Reuters) Back to slideshow navigation
  16. Saluting the 'goddess'

    Will Smith and Jada Pinkett Smith also joined Winfrey on the stage. The couple started off the taping of the second show, which will air on Tuesday, May 24. Pinkett Smith, right, thanked Winfrey and told her she mothered millions and "that puts you in the status of a goddess." (Daniel Boczarski / Getty Images) Back to slideshow navigation
  17. No couch this time

    Tom Cruise, famous for his couch jumping on Winfrey's show, was among the stars at "Surprise Oprah!" on Tuesday, May 17. "You always had the power, and that is the message you brought into our lives," Cruise told Winfrey. (John Gress / Reuters) Back to slideshow navigation
  18. Girl power

    Beyonce sings "Run the World (Girls)," backed by dozens of dancers, during "Surprise Oprah! A Farewell Spectacular." (Peter Wynn Thompson / AFP - Getty Images) Back to slideshow navigation
  19. Just a few of her friends

    Oprah Winfrey is kissed by singer Usher, third from left, next to actor Will Smith, center, former NBA star Michael Jordan, third from right, actor Tom Cruise, second from right, talk host Rosie O'Donnell, right, and Simon Cowell, left, during the taping of "Surprise Oprah!" on Tuesday, May 17. (John Gress / Reuters) Back to slideshow navigation
  20. Farewell

    Oprah Winfrey wiped away tears as celebrity after celebrity surprised her during a farewell double-episode taping of "The Oprah Winfrey Show" that will precede her finale. "Thank you is not enough, but thank you," Winfrey told the crowd of 13,000 gathered at Chicago's United Center on Tuesday, May 17 for "Surprise Oprah! A Farewell Spectacular." "For your love and your support, thank you." (Peter Wynn Thompson / AFP - Getty Images) Back to slideshow navigation
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  1. Image: Surprise Oprah! A Farewell Spectacular
    Daniel Boczarski / Getty Images
    Above: Slideshow (20) Oprah's farewell spectacular
  2. Image:
    Anne Marie Fox / AP
    Slideshow (34) It's Oprah's world

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