1. Headline
  1. Headline
updated 2/17/2009 8:20:58 PM ET 2009-02-18T01:20:58

A family desperate to save a child from a lethal brain disease sought highly experimental injections of fetal stem cells — injections that triggered tumors in the boy's brain and spinal cord, Israeli scientists reported Tuesday.

  1. More from TODAY.com
    1. Social media tipsters hope to solve Philadelphia hate crime case

      Social media sometimes gets a bad rap as the scourge of modern society, but in Philadelphia this week, police are hopeful ...

    2. Family lauds Miranda Lambert for concert gesture
    3. Why one dad hates homework as much as his kid does
    4. Mom's home! Toddler ignores military protocol, runs into soldier's arms
    5. For the win: TODAY fans pass along pics of their girls on the gridiron

Scientists are furiously trying to harness different types of stem cells — the building blocks for other cells in the body — to regrow damaged tissues and thus treat devastating diseases. But for all the promise, researchers have long warned that they must learn to control newly injected stem cells so they don't grow where they shouldn't, and small studies in people are only just beginning.

Tuesday's report in the journal PLoS Medicine is the first documented case of a human brain tumor — albeit a benign, slow-growing one — after fetal stem cell therapy, and hammers home the need for careful research. The journal is published by the Public Library of Science.

"Patients, please beware," said Dr. John Gearhart, a stem cell scientist at the University of Pennsylvania who wasn't involved in the Israeli boy's care but who sees similarly desperate U.S. patients head abroad to clinics that offer unproven stem cell injections.

"Cells are not drugs. They can misbehave in so many different ways, it just is going to take a good deal of time" to prove how best to pursue the potential therapy, Gearhart said.

Fatal disease
The unidentified Israeli boy has a rare, fatal genetic disease with a tongue-twisting name — ataxia telangiectasia, or A-T. Degeneration of a certain brain region gradually robs these children of movement. Plus, a faulty immune system leads to frequent infections and cancers. Most die in their teens or early 20s.

Israeli doctors pieced together the child's history: When he was 9, the family traveled to Russia, to a Moscow clinic that provided injections of neural stem cells from fetuses — immature cells destined to grow into a main type of brain cells. The cells were injected into his brain and spinal cord twice more, at ages 10 and 12.

Slideshow: Perspectives on stem cell research Back home in Israel at age 13, the boy's A-T was severe enough to require that he use a wheelchair when he also began complaining of headaches. Tests at Sheba Medical Center in Tel Aviv uncovered a growth pushing on his brain stem and a second on his spinal cord. Surgeons removed the spinal cord mass when the boy was 14, in 2006 and they say his general condition has remained stable since then.

But was the boy prone to tumors anyway or were the fetal stem cells to blame? A Tel Aviv University team extensively tested the tumor tissue and concluded it was the fetal cells. Among other evidence, some of the cells were female and had two normal copies of the gene that causes A-T — although that boy's underlying poor immune function could have allowed the growths to take hold.

Using stem cells from multiple fetuses that also were mixed with growth-spurring compounds "may have created a high-risk situation where abnormal growth of more than one cell occurred," wrote lead researcher Dr. Ninette Amariglio of Sheba Medical. She urged better research to "maximize the potential benefits of regenerative medicine while minimizing the risks."

This brain disease wasn't conducive to stem cell therapy in the first place, said stem cell specialist Dr. Marius Wernig of Stanford University, who said it's unclear exactly what was implanted.

"Stem cell transplantations have a humongous potential," Wernig said. But "if people rush out there without really knowing what they're doing ... that really backfires and can bring this whole field to a halt."

© 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Discuss:

Discussion comments

,

Most active discussions

  1. votes comments
  2. votes comments
  3. votes comments
  4. votes comments

More on TODAY.com

  1. Courtesy of Jessica Hester

    Family lauds Miranda Lambert for concert gesture

    9/18/2014 12:34:48 AM +00:00 2014-09-18T00:34:48
  1. Twitter cia Greg Bennett

    Social media tipsters hope to solve Philadelphia hate crime case

    9/17/2014 11:25:24 PM +00:00 2014-09-17T23:25:24
  1. Obama: US will not fight another ground war in Iraq

    The U.S. will not send armed forces to fight a ground war in Iraq, President Barack Obama told service members at U.S. Central Command in Tampa, Florida, a day after his top military adviser said he could envision recommending the president deploy ground troops.

    9/17/2014 3:51:00 PM +00:00 2014-09-17T15:51:00
  1. Why one dad hates homework as much as his kid does

    9/17/2014 9:06:38 PM +00:00 2014-09-17T21:06:38