1. Headline
  1. Headline
updated 2/23/2007 1:07:50 PM ET 2007-02-23T18:07:50

In an “extraordinary development” in the fight against AIDS, a medical journal article published Friday says that conclusive data shows there is no question circumcision reduces men’s chances of catching HIV by up to 60 percent.

  1. More from TODAY.com
    1. 'It can happen to any American': Mom whose son died in hot car aims to help others

      The mother of a toddler who died after his father left him in a car said she remembers hearing about such tragedies every ...

    2. Celebrity photo hacks: How to keep your information secure in the cloud
    3. First photos of Angelina Jolie and Brad Pitt's wedding emerge
    4. Brazen bike bandits caught on camera
    5. 'Be a man': Clint Eastwood's son, Scott, reveals dad's best advice

The question now is how to put that fact to work to combat AIDS across Africa.

The findings were first announced in December, when initial results from two major trials — in Kenya and Uganda — showed promising links between circumcision and HIV transmission. However, those trials were deemed so definitive that the tests were halted early.

The full data from the trials, carried out by the U.S. National Institutes of Health, were published Friday in The Lancet.

“This is an extraordinary development,” said Dr. Kevin de Cock, director of the World Health Organization’s AIDS department. “Circumcision is the most potent intervention in HIV prevention that has been described.”

Circumcision has long been suspected of reducing men’s susceptibility to HIV infection because the cells in the foreskin of the penis are especially vulnerable to the virus.

A modeling study last year projected that in the next decade, male circumcision could prevent 2 million AIDS infections and 300,000 deaths. Last year, 2.8 million people in sub-Saharan Africa became infected with HIV, and 2.1 million people died.

Experts say the breakthrough’s significance is on par with the identification of the virus and the use of lifesaving combination drug therapy.

The two U.S. studies confirm similar results from an earlier trial in South Africa.

But experts warn that solid evidence is not justification for mass circumcisions, noting that African health systems are already overburdened, and circumcision requires more planning than, for example, an immunization campaign.

“It’s a tricky one, but it’s something we’re going to have to move on,” said Dr. Catherine Hankins, a scientific adviser at UNAIDS. “Male circumcision is such a sensitive religious and cultural issue that we need to be careful.”

Several African countries have met with U.N. agencies to explore strategies for increasing circumcision.

Together with the United Nations AIDS agency, WHO is convening a meeting in Switzerland in March to evaluate the data and decide the next steps in slowing the AIDS pandemic.

In the Kenyan study, 1,391 circumcised men were compared to 1,393 who were not. And in Uganda, 2,474 circumcised men were compared to 2,522 men who were not. Scientists tracked the men for two years and found that those who were circumcised were 51-60 percent less likely to contract HIV.

© 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Discuss:

Discussion comments

,

Most active discussions

  1. votes comments
  2. votes comments
  3. votes comments
  4. votes comments

More on TODAY.com

  1. Brazen bike bandits caught on camera

    NBC national investigative correspondent Jeff Rossen and his team locked a bike to a tree in San Francisco and not only captured its theft on camera, but followed it on its journey after being stolen.

    9/2/2014 1:24:01 PM +00:00 2014-09-02T13:24:01