Aug. 16, 2011 at 1:34 PM ET
Remember when "Grey's Anatomy" creator Shonda Rhimes said in May that the upcoming season "might be the final season for the (original cast members)"?
The new trailer for the show appears to be setting up at least one exit. Warning: If you don't want any spoilers, don't watch the clip!
Then again, another cast member has survived this particular type of exit before, only to return and flourish.
"Grey's Anatomy" returns with a two-hour episode on Sept. 22 at 9 p.m. on ABC.
Who -- if anyone -- from the original cast would you like to see leave the show this season? Tell us on our Facebook page.